Cholinergic treatments with emphasis on M1 muscarinic agonists as potential disease-modifying agents for Alzheimer’s disease
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چکیده
منابع مشابه
Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia
Alzheimer's disease (AD) and schizophrenia (SZ) are neurological disorders with overlapping symptomatology, including both cognitive deficits and behavioral disturbances. Current clinical treatments for both disorders have limited efficacy accompanied by dose-limiting side effects, and ultimately fail to adequately address the broad range of symptoms observed. Novel therapeutic options for AD a...
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The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...
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The first drugs developed for Alzheimer's disease (AD), acetylcholinesterase inhibitors (AChEI), increase acetylcholine levels, previously demonstrated to be reduced in AD. To date, four AChEI are approved for the treatment of mild-to-moderate AD. A further therapeutic option available for moderate-to-severe AD is memantine. These treatments are symptomatic, whereas drugs under development are ...
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far are consistent with this hypothesis. In other words there is no significant evidence for non-allelic genetic heterogeneity in the families tested yet. T h e localization of a familial Alzheimer’s disease gene to the proximal end of the long arm of chromosome 2 1 is only the start of the endeavour to isolate the gene itself. Work in several laboratories is presently being directed towards de...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2008
ISSN: 1933-7213,1878-7479
DOI: 10.1016/j.nurt.2008.05.002